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Extracted activity across all voxels of a bilateral medial temporal lobe ROI, comprised of hippocampus and parahippocampal gyrus, in groups of subjects defined by combined APOE and CLU risk allele status. Error bars represent standard errors of the means. APOE-ε4 and CLU-C show an additive effect whereby increasing AD genetic risk is associated with decreasing bilateral medial temporal lobe activity during executive attention.
