. Author manuscript; available in PMC: 2015 May 5.

Published in final edited form as: J Pediatr Rehabil Med. 2014;7(2):159–165. doi: 10.3233/PRM-140285

Table 2.

Bone marker and formation/resorption ratio comparison between MPS versus control groups, adjusted for sex and Tanner group

Biomarker	N	Additive Difference (95% CI)	P-value
BSAP (U/L)	89	27.5 (−0.5, 55.6)	0.054
DPD (nmol/mmol creatinine)	86	3.0 (−13.9, 19.9)	0.721
PYD (nmol/mmol creatinine)	86	87.7 (−12.0, 187.4)	0.084
OCN (ng/ml)	90	12.7 (6.2, 19.1)	<0.001

*Formation/Resorption*	N	*Multiplicative* *Difference (95% CI)*	*P-value*

BSAP/DPD	86	1.50 (0.98, 2.30)	0.062
BSAP/PYD	86	1.58 (1.08, 2.33)	0.019
OCN/DPD	86	1.40 (0.99, 1.99)	0.057
OCN/PYD	86	1.43 (1.08, 1.89)	0.012

Tanner stage is grouped into three categories of 1, 2 or 3, and 4 or 5.

MPS=Mucopolysaccharidoses; OCN=osteocalcin; PYD=pyridinoline; DPD=deoxypyridinoline; BSAP=bone specific alkaline phosphatase