Table 2. Adverse events by formulation.

Overall Events	Severity	Overall		RF TFV		RGVF TFV		VF TFV
		N	%	N	%	N	%	N	%
	Grade 1	25	86.21	7	100.00	7	87.50	11	78.57
	Grade 2	2	6.90	0	0.00	1	12.50	1	7.14
	Grade 3	2	6.90	0	0.00	0	0.00	2	14.29
	Total	29	100	7	100	8	100	14	100
Overall Events By System
Gastrointestinal	Grade 1—Mild	17	94.44	5	100	5	83.33	7	100
Gastrointestinal	Grade 2—Moderate	1	5.56	0	0.00	1	16.67	0	0.00
Total		18	100	5	100	6	100	7	100
Genitourinary	Grade 2—Moderate	1	33.33	0	0.00	0	0.00	1	33.33
Genitourinary	Grade 3—Severe	2	66.67	0	0.00	0	0.00	2	66.67
Total		3	100	0	0.00	0	0.00	3	100
HEENT	Grade 1—Mild	2	100	0	0.00	2	100	0	0.00
Total		2	100	0	0.00	2	0.00	0	0.00
Neurological	Grade 1—Mild	5	100	2	100	0	0.00	3	100
Total		5	100	2	100	0	0.00	3	100
Respiratory	Grade 1—Mild	1	100	0	0.00	0	0.00	1	100
Total		1	100	0	0.00	0	0.00	1	100
Proportion of participants with≥ Grade 2 adverse events				0	0.00	1	7.69	1	7.69