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. 2015 May 5;10(5):e0125553. doi: 10.1371/journal.pone.0125553

Fig 4. Four downregulated tissue miRNAs were detected in serum samples of untreated and SSA-treated SI-NET patients at all stages.

Fig 4

MiR-31, -129-5p, -133a and -215 levels did not show any different expression at all different stages of SSA-treated SI-NET patients vs untreated patients. The QRT-PCR analysis included 21 untreated patients (PT 1–7, LNM 1–7 and LM 1–7) and 21 SSA-treated patients (SSA-PT 8–14, SSA-LNM 8–14 and SSA-LM 8–14). Results were plotted using the 2-ΔΔCt method with miR-16 expression (set to 1) from each individual sample for normalization. Significance was calculated by One-Way ANOVA followed by the Dunnett’s test. * = p < 0.05, ** = p < 0.01 and *** = p < 0.001.