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. 2015 May 5;10(5):e0125553. doi: 10.1371/journal.pone.0125553

Fig 6. Four downregulated tissue miRNAs were detected in untreated and SSA-treated SI-NET patients at LM stage in serum samples collected at UU and UCL.

Fig 6

Total RNA was isolated from UU collection, including three healthy donors (HD 4–6), three untreated liver metastases (LM 3–5) and three SSA-treated liver metastases (SSA-LM 11–13). Total RNA was also isolated from UCL collection, including three healthy donors (HD 12–14), three untreated liver metastases (LM 17–19) and three SSA-treated liver metastases (SSA-LM 26–28). MiR-31, -129-5p, -133a and -215 levels were significantly lower in 6 untreated LM patients and 6 SSA-treated LM patients vs 6 HD. Results were plotted using the 2-ΔΔCt method with miR-16 expression (set to 1) from each individual sample for normalization. Significance was calculated by One-Way ANOVA followed by the Bonferroni test. * = p < 0.05, ** = p < 0.01 and *** = p < 0.001.