Table 4. Molecular pathways and associated proteins in PMS subtype.

KEGG ID	KEGG Term	Term P values Corr Bonf	Times Found	Pathway Assoc. Genes Found in Subnetworks	Pathway Associated Genes Not Found in Subnetworks
KEGG:04614	Renin-angiotensin system	6,88E-06	5	AGT, MAS1	ACE, ACE2, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MME, NLN, REN, THOP1
KEGG:04977	Vitamin digestion and absorption	2,7E-06	1	APOA4, APOA1, SCARB1	ABCC1, APOB, AWAT2, BTD, C20orf54, CUBN, FOLH1, GIF, LMBRD1, LRAT, MMACHC, PLB1, PNLIP, RBP2, SLC19A1, SLC19A2, SLC19A3, SLC23A1, SLC46A1, SLC5A6, TCN2
KEGG:04330	Notch signaling pathway	8,9E-07	1	NOTCH2, EP300, PSEN1, DTX1, JAG2	ADAM17, APH1A, CIR1, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, HDAC1, HDAC2, HES1, HES5, JAG1, KAT2A, KAT2B, LFNG, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH3, NOTCH4, NUMB, NUMBL, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1
KEGG:04610	Complement and coagulation cascades	3,9E-09	1	KNG1, F12, A2M, F2, SERPING1, SERPINA1, PLG	BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F13A1, F13B, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PROC, PROS1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, TFPI, THBD, VWF

Molecular pathways and associated proteins in PMS subtype were shown. Individual protein list of each PMS patients were processed and compared with control samples regarding their fold changes. Table shows the targeted KEGG pathways with the database ID and names. P values were given with the Bonferroni Corrections. ‘Times found’ indicates the co-occurrence of target proteins in subnetworks. Other pathway-associated proteins that are not found in subnetworks were also listed.