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. 2015 May 5;10(5):e0125910. doi: 10.1371/journal.pone.0125910

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© 2015 Bao et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 9 — Based on our studies and other reports, we propose a model in which flagellin binds toTLR5 and transmits its signal to PI3K via MyD88. Activated PI3K stimulatesAkt/mTOR, and mTOR signaling activates NF-κB and STAT3. These factors translocate to the nucleus and enhance TNF-α and IL-6 expression, promoting cell proliferation and survival.