Table 1.

Adverse Reactions (AR) after Cryopreserved HSC Transplantation

Adverse Reaction category	Symptoms	Reference	Adverse Reaction (AR) Incidence
Allergy	Flushing, rash, pruritus, erythema	(5,10,18,39,59,61–64)	Cordoba(4): 67.36% developed AR. Specifically, 43.75% allergic reactions 25% gastrointestinal symptoms 20.83% respiratory symptoms 11.81% cardiovascular 3.47% neurological symptoms Donmez(8): 25.25% developed AR. Specifically, 7.73% cardiac AR 1.54% sinus bradycardia 15.97% non-cardiac AR Kersting(14): Nephropathy incidence 0~29% Konuma(15): 58% systolic hypertension, 64% diastolic hypertension 32% bradycardia Alessandrino(31): 8% non-cardiac complications 57.33% cardiac AR, where 36% hypertension Zambelli(44): 50% developed AR, wherein 22% hypotension 4.54% hypertension 4.5% bradycardia Hazar(65): for children 34–50% renal insufficiency in the early phases 41%, 31% and 11% renal inefficiency at 1, 3 and 7 years after infusion, respectively Graves(66): 0.4% severe AR and 50% non- cardiac AR Keung(67): 65% sinus bradycardia 29.41% heart block 41% hypertension 82% arrhythmias Lopez-Jimenez(68): 41% non-cardiac AR no bradycardia and arrhythmias
	Edema, anasarca	(8,18)
	Bronchospasm	(61)
Gastro-intestinal	Headache	(5,7–9,15,18,69)
	Chest tightness, dyspnea	(5,9,15,62,63)
	Abdominal cramping/pain, gastrointestinal distress, diarrhea	(5,8,14,16,18,59,61–63,69)
	Nausea, emesis, vomiting	(5,8,12,15,16,18,39,43,63)
Renal	Hemoglobinuria, proteinuria, mild azotemia	(59,69,70)
	Hemolytic-uremic syndrome (HUS)	(70)
	Urine incontinence	(11,71)
	Thrombocytopenia, hemolytic anemia	(14,70)
	Renal insufficiency, nephropathy, acute renal failure	(14,64,65,70,72,73)
Cardio-vascular	Hypotension, hypertension	(5,8,12,14–16,18,31,40,61–63,67)
	Arrhythmias/bradycardia, tachycardia	(6,8,12,15,17,18,20,43,61–63,67,69,73)
	Hypothermia, hyperthermia	(5,8,16,17,70,73)
	Rigor, tremor	(8,39,70)
	Ischemia, hypoxia	(39,40,43)
	Syncope, coma, somnolence, shock, loss of consciousness, trismus	(10,11,19,40,43,74–76)
	Respiratory arrest, shortness of breath, cardiac arrest, coronary artery spasm	(10,12,16,18,19,33,40,43,59,61,64, 77)
	Seizure	(5,10,12,14,19,73, 74)
	Heart block	(18,63,67)
Neurological	Mydriasis, miosis, Dysarthria, bilateral thalamic infarction, ophthalmic deviation, blurred vision	(9–12,19,71)
	Dysgeusia	(59)
	Reversible leukoencephalopathy (RPL), severe encephalopathy,	(39,40,71,73,74)
	Central nervous system affected	(10,64)
	Transient global amnesia	(9,19,36,43,71)
	Cerebral infarction	(36,43)
	Cognition problem	(9,39,43,71)
	Numbness, muscle weakness	(8,9,40,43,71)
	Mental acuity, anxiety	(39,71)
Hepatic	Progressive jaundice	(64,70)