Fig 1. Clustering analysis of significant genes in rat UCMSC (rUCMSC) and human UCMSC (hUCMSC) co-cultured with mammary carcinoma cells of their respective species; Mat B III rat breast carcinoma cells or MDA-231 human breast carcinoma cells.

The genes differentially expressed between naïve human or rat UCMSC and those co-cultured with mammary carcinoma cells are listed on the row and the samples are shown on the column. Red are higher expression and black to green are lower expression. This analysis suggests that a short time co-culture with mammary carcinoma cells significantly modifies expression of multiple tumor-suppressor and-promoter genes in both human and rat UCMSC.