Figure 2.

Sequence alignment of ELR1 with other TNFRs. (A) Schematic representation of the domain organization of ELR1. Features include a signal peptide (SP, blue), four complete cysteine rich domains (CRD, green) and a membrane-spanning domain (MS, orange). (B) Sequence alignment between TNFR members by ClustalW.⁴⁰ The sequences aligned are in the order: ELR1, HVEM, TNFR2, CD134 and TNFR1. Each CRD can be subdivided in two structural entities or modules and each module has been named (A1, B2, etc.) according to the definition adopted by Naismith.¹⁶ Within each CRD, cysteines forming disulfide bonds are in green.