Table 2.
Gene ontology (biological process) of differentially expressed genes between the two groups
| GO classification | GO term | GO ID | C | O | E | R | rawP | adjP |
|---|---|---|---|---|---|---|---|---|
| Biological process | Sterol metabolic process | GO:0016125 | 107 | 12 | 1.07 | 11.2 | 8.29E-10 | 1.06E-06 |
| Cholesterol metabolic process | GO:0008203 | 100 | 11 | 1 | 10.98 | 5.24E-09 | 3.35E-06 | |
| Steroid metabolic process | GO:0008202 | 238 | 14 | 2.38 | 5.87 | 1.40E-07 | 5.96E-05 | |
| Regulation of immune system process | GO:0002682 | 695 | 23 | 6.96 | 3.3 | 5.97E-07 | 0.0002 | |
| Lipid metabolic process | GO:0006629 | 944 | 27 | 9.46 | 2.86 | 1.03E-06 | 0.0003 | |
| Alcohol metabolic process | GO:0006066 | 254 | 13 | 2.54 | 5.11 | 1.89E-06 | 0.0004 | |
| Monocarboxylic acid metabolic process | GO:0032787 | 367 | 15 | 3.68 | 4.08 | 4.94E-06 | 0.0008 | |
| Sterol biosynthetic process | GO:0016126 | 43 | 6 | 0.43 | 13.93 | 4.24E-06 | 0.0008 | |
| Oxidation-reduction process | GO:0055114 | 919 | 25 | 9.21 | 2.72 | 6.38E-06 | 0.0009 | |
| Single-organism biosynthetic process | GO:0044711 | 385 | 15 | 3.86 | 3.89 | 8.76E-06 | 0.0011 | |
| Mitotic cell cycle | GO:0000278 | 542 | 18 | 5.43 | 3.32 | 1.00E-05 | 0.0012 | |
| Oxoacid metabolic process | GO:0043436 | 718 | 21 | 7.19 | 2.92 | 1.25E-05 | 0.0012 | |
| Cytolysis | GO:0019835 | 30 | 5 | 0.3 | 16.64 | 1.12E-05 | 0.0012 | |
| Organic acid metabolic process | GO:0006082 | 732 | 21 | 7.33 | 2.86 | 1.67E-05 | 0.0015 | |
| Carboxylic acid metabolic process | GO:0019752 | 676 | 20 | 6.77 | 2.95 | 1.72E-05 | 0.0015 | |
| Cell cycle | GO:0007049 | 1136 | 27 | 11.38 | 2.37 | 3.00E-05 | 0.0021 | |
| Small molecule biosynthetic process | GO:0044283 | 373 | 14 | 3.74 | 3.75 | 2.64E-05 | 0.0021 | |
| Lipid biosynthetic process | GO:0008610 | 428 | 15 | 4.29 | 3.5 | 3.02E-05 | 0.0021 | |
| Cholesterol biosynthetic process | GO:0006695 | 37 | 5 | 0.37 | 13.49 | 3.25E-05 | 0.0022 | |
| Steroid biosynthetic process | GO:0006694 | 125 | 8 | 1.25 | 6.39 | 3.87E-05 | 0.0025 | |
| Regulation of lipid biosynthetic process | GO:0046890 | 96 | 7 | 0.96 | 7.28 | 5.18E-05 | 0.0031 | |
| Triglyceride metabolic process | GO:0006641 | 69 | 6 | 0.69 | 8.68 | 6.71E-05 | 0.0039 | |
| Small molecule metabolic process | GO:0044281 | 1824 | 36 | 18.27 | 1.97 | 7.08E-05 | 0.0039 | |
| Triglyceride biosynthetic process | GO:0019432 | 23 | 4 | 0.23 | 17.36 | 7.49E-05 | 0.004 | |
| Immune system process | GO:0002376 | 1353 | 29 | 13.55 | 2.14 | 9.52E-05 | 0.0041 | |
| Neutral lipid biosynthetic process | GO:0046460 | 26 | 4 | 0.26 | 15.36 | 0.0001 | 0.0041 | |
| Acylglycerol metabolic process | GO:0006639 | 79 | 6 | 0.79 | 7.58 | 0.0001 | 0.0041 | |
| Complement activation, alternative pathway | GO:0006957 | 10 | 3 | 0.1 | 29.95 | 0.0001 | 0.0041 | |
| Acylglycerol biosynthetic process | GO:0046463 | 26 | 4 | 0.26 | 15.36 | 0.0001 | 0.0041 | |
| Alcohol biosynthetic process | GO:0046165 | 109 | 7 | 1.09 | 6.41 | 0.0001 | 0.0041 | |
| Cellular lipid metabolic process | GO:0044255 | 667 | 18 | 6.68 | 2.69 | 0.0001 | 0.0041 | |
| Neutral lipid metabolic process | GO:0006638 | 81 | 6 | 0.81 | 7.39 | 0.0002 | 0.0075 | |
| Cell cycle phase | GO:0022403 | 617 | 17 | 6.18 | 2.75 | 0.0002 | 0.0075 | |
| Positive regulation of immune system process | GO:0002684 | 440 | 14 | 4.41 | 3.18 | 0.0002 | 0.0075 | |
| Retinoic acid catabolic process | GO:0034653 | 3 | 2 | 0.03 | 66.55 | 0.0003 | 0.0101 | |
| Saturated monocarboxylic acid metabolic process | GO:0032788 | 3 | 2 | 0.03 | 66.55 | 0.0003 | 0.0101 | |
| Unsaturated monocarboxylic acid metabolic process | GO:0032789 | 3 | 2 | 0.03 | 66.55 | 0.0003 | 0.0101 | |
| Diterpenoid catabolic process | GO:0016103 | 3 | 2 | 0.03 | 66.55 | 0.0003 | 0.0101 | |
| Death | GO:0016265 | 1475 | 29 | 14.78 | 1.96 | 0.0004 | 0.0122 | |
| Myeloid leukocyte differentiation | GO:0002573 | 131 | 7 | 1.31 | 5.33 | 0.0004 | 0.0122 |
Fold change >1.5, P < 0.05. adjP, P-value adjusted by the multiple test adjustment; C, the number of reference genes in the category; GO, Gene Ontology, O, the number of genes in the gene set and category; E, the expected number in the category; R, ratio of enrichment; rawP, P-value from hypergeometric test.