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. 2015 Feb 20;19(5):1055–1064. doi: 10.1111/jcmm.12498

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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TEM analysis of tumour tissues derived from tumour-bearing nude mice. Tumours were removed from killed animals on Day 10 after drug administration. (A) Tumour section derived from control animal. (B) Tumour section derived from animals received intratumoural injection of aurantiamide acetate. Boxed areas in (B) were enlarged in (a). N = 5 for each group. Scale bars in (A) and (B), 1 μm; scale bar in (a), 0.5 μm. (C) The number of autophagosomes and autolysosomes per cell was calculated from 12 micrographs. **P < 0.01 compared with control.