Table 3. Demographic, clinical, and pathologic characteristics by latent groups.
| Mean (SD) or N (%) | Group 1 (N=389) | Group 2 (N=304) | Group 3 (N=114) | Group 4 (N=69) | p-value |
|---|---|---|---|---|---|
| Study (ROS) | 214 (55.0%) | 158 (52.0%) | 55 (48.3%) | 44 (63.8) | 0.1862 |
| # follow-up years | 7.1 (4.2) | 6.6 (3.8) | 6.9 (2.7) | 7.2 (4.0) | .5173 |
| Age at baseline (in years) | 79.3 (6.9) | 81.2 (6.6) | 81.4 (7.1) | 79.6 (6.6) | <.0011 |
| Age at death (in years) | 87.4 (6.5) | 89.0 (6.5) | 89.6 (6.6) | 88.1 (6.5) | .0011 |
| Male sex | 143 (36.7%) | 107 (35.2%) | 29 (25.4%) | 18 (26.1%) | .0672 |
| Education (in years) | 16.5 (3.6) | 16.4 (3.6) | 16.3 (3.5) | 17.0 (4.4) | .5151 |
| Baseline cognition | 0.17 (0.4) | -0.29 (0.5) | 0.06 (0.4) | -0.16 (0.7) | <.0011 |
| Pathologic AD | 188 (48.3%) | 205 (67.4%) | 98 (86.0%) | 46 (66.7%) | <.0012 |
| Macroscopic infarcts | 109 (28.0%) | 110 (36.2%) | 47 (41.2%) | 37 (53.6%) | <.0012 |
| Neocortical Lewy bodies | 26 (6.7%) | 38 (12.5%) | 21 (18.4%) | 17 (24.6%) | <.0012 |
| Hippocampal sclerosis | 16 (4.1%) | 34 (11.2%) | 15 (13.2%) | 5 (7.3%) | .0012 |
Demographic and clinical measures are taken at study baseline except for age at death; and pathology measures are taken at autopsy.
SD: Standard deviation.
1
ANOVA (df=3);
2
Chi Square (df=3);
3
Kruskal-Wallis Test (df=3).