Table 3.
Unstandardized regression coefficients and associated p-values (in parentheses) for clinical and cytokine markers included in the final model selected by minimizing AIC for each brain volumetric measure. Rows indicate the predictors under consideration, and each final regression model is represented by one column of the table. Statistically significant covariates are highlighted in grey. AIC and adjusted R2 values of the final models are included in the final rows.
| Cortex | White Matter | Caudate | Putamen | Globus Pallidus | Thalamus | Hippo-campus | Amygdala | Ventricles | |
|---|---|---|---|---|---|---|---|---|---|
| Age | -1.95e+3 (<.0001) | -7.30e+2 (0.0635) | -1.62e+1 (0.0764) | -4.30e+1 (0.0001) | -1.18e+1 (0.0019) | -5.81e+1 (<.0001) | -2.10e+1 (0.0093) | -8.44e+0 (0.0428) | 4.41e+2 (<.0001) |
| CD4 current | -5.60e-1 (0.1468) | 2.78e-1 (0.0626) | 7.59e+0 (0.0353) | ||||||
| CD4 nadir | 1.75e+2 (0.0204) | 4.73e+1 (0.0795) | 1.97e+2 (0.0311) | 1.21e+2 (0.0445) | |||||
| HIV RNA | |||||||||
| HIV duration | -1.21e+3 (0.0355) | -3.18e+1 (0.0672) | |||||||
| CART | 2.58e+4 (0.0166) | 6.86e+2 (0.0342) | 6.35e+2 (0.0053) | ||||||
| HCV | 3.48e+2 (0.0964) | 4.96e+2 (0.0361) | 3.48e+2 (0.0009) | ||||||
| IFN-γ | 2.23e+4 (0.0114) | 2.41e+4 (0.0306) | 4.79e+2 (0.1370) | 4.24e+2 (0.0687) | |||||
| IL1-β | -1.22e+4 (0.1490) | -2.32e+2 (0.0069) | |||||||
| IL6 | -2.19e+4 (0.0095) | -6.21e+2 (0.0030) | -8.36e+2 (0.0021) | -4.82e+2 (0.0081) | 6.56e+3 (0.0003) | ||||
| IL8 | |||||||||
| IL10 | -2.53e+2 I (0.0526) | -9.03e+3 (0.0190) | |||||||
| IL16 | -2.48e+4 (0.0001) | -2.55e+2 (0.1253) | -6.63e+2 (0.0014) | -2.18e+2 (0.0038) | -2.37e+2 (0.1263) | -2.04e+2 (0.0091) | |||
| IL18 | -1.21e+4 (0.0023) | 2.37e+2 (0.1184) | 1.52e+2 (0.1436) | ||||||
| IP10 | 3.82e+3 (0.1153) | 4.99e+3 (0.1240) | -5.15e+1 (0.1450) | ||||||
| MCP1 | 7.44e+3 (0.0924) | 4.01e+2 (0.0127) | 1.38e+2 (0.0150) | 3.03e+2 (0.0691) | 1.29e+2 (0.0218) | ||||
| MIP-1β | 1.39e+2 (0.1325) | 2.47e+3 (0.0184) | |||||||
| SDF1-α | |||||||||
| TNF-α | |||||||||
| TRAIL | 4.46e+2 (0.0663) | ||||||||
| ICV | 2.31e-1 (<.0001) | 2.70e-1 (<0001) | 4.87e-3 (<.0001) | 4.51e-3 (<.0001) | 1.64e-3 (<.0001) | 7.57e-3 (<.0001) | 3.78e-3 (<0001) | 1.63e-3 (<.0001) | 2.17e-2 (0.0001) |
| Final AIC Adjusted R2 | 1494.88 0.8377 | 1528.72 0.7692 | 977.03 0.6283 | 999.36 0.6764 | 842.38 0.6289 | 1016.12 0.7893 | 959.31 0.6477 | 865.53 0.5357 | 1336.36 0.4142 |
Note: ICV = intracranial volume.