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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Clin Immunol. 2015 Mar 28;158(1):103–113. doi: 10.1016/j.clim.2015.03.018

Figure 7.

Figure 7

Efficacy of FTY720 in inhibiting EAE in Cbl-b−/− mice. EAE was induced in WT and Cbl-b−/− mice by s.c. immunization with 165 µg of MOG35–55 and 300 µg of CFA. 150 ng of Pertussis toxin was also given i.p. on day 0 and 2. On the day of EAE-induction, the mice were administered either 0.375 mg/kg of FTY720 (FTY) or vehicle (VC) via gavage. FTY720 or vehicle was then administered every five days until day 20. Clinical scores: 1 = tail flaccidity, 2 = abnormal gait, 3 = hind leg paralysis, 4 = front leg paralysis, 5 = death. The disease severity differed significantly between the VC-treated WT group vs. the VC-treated Cbl-b−/− group, ***p=0.0004. In addition, the disease severity differed significantly between the VC-treated WT group vs. the FTY720-treated WT group, ****p<0.0001, and also between the VC-treated Cbl-b−/− group vs. the FTY720-treated Cbl-b−/− group, ****p<0.0001 by Mann-Whitney test. The data shown are from two independent experiments (n = 7–8/treatment group in total).