Table 4.
Changes in migraine and headache frequency during use of the progestin-only pill desogestrel 75 μg, comparison between MO (n=32) and MA (10) patients
| MO Mean (SD) baseline | MA Mean (SD) baseline | MO Mean (SD) TP 2 | MA Mean (SD) TP 2 | p-value MO baseline vs. TP 2 | p-value MA baseline vs. TP 2 | |
|---|---|---|---|---|---|---|
| Headache days/month | 4.1 (4.3) | 3.8 (5.2) | 3.4 (4.6) | 1.9 (2.0) | 0.06 | 0.60 |
| Migraine days/month | 5.4 (4.1) | 6.8 (4.8) | 3.2 (3.8) | 4.6 (4.3) | 0.007 | 0.09 |
| Sum headache and migraine/month | 9.5 (5.6) | 8.8 (3.6) | 6.6 (4.4) | 6.6 (4.4) | <0.001 | 0.11 |
| Headache intensity/month | 16.0 (8.3) | 14.4 (5.4) | 11.4(8.4) | 8.5 (6.4) | <0.001 | 0.24 |
| Pain medication | 6.2 (3.6) | 9.8 (9.5) | 4.7 (3.6) | 5.8 (4.8) | 0.03 | 0.03 |
| Triptan use in 3 months | 11.9 (11.8) | 13.1 (22.2) | 8.4 (10.7) | 6.2 (8.6) | 0.005 | 0.02 |
MO = migraine without aura, MA = Migraine with aura, baseline : days 1–90 before treatment; TP 2: days 91–180 of treatment.