Figure 6.

Increased failure of antidromic APs by membrane-permeable, but not membrane-impermeable, BK channel blockers. A, No significant effect of iberiotoxin (250 nm) on the antidromic APs at 100 Hz. B, Increased failure of antidromic APs by paxilline (10 μm) at 100 Hz. The arrowheads indicate failures. C, Pooled data for paxilline (n = 6). *p = 0.015 (at 200 Hz) and 0.001 (at 300 Hz). D, The failure rate at 200 Hz stimulation before and after the paxilline application. p = 0.02. E, Decrease of the maximum net firing rate after the paxilline treatment. *p = 0.03.