Table 1.
Changes in the peak current amplitudes and rates in receptor desensitization during repetitive agonist application
| ATP Applications, 100 μM |
||||
|---|---|---|---|---|
| Parameters | 1st | 2nd | 3rd | 4th |
| τdes, s | 13.4 ± 3.4 (7) | 7.3 ± 1.7 (7) | 5.2 ± 0.4 (6) | 3.3 ± 0.6 (4) |
| Imax, pA/pF | 274 ± 25 (7) | 215 ± 32 (7) | 204 ± 37 (6) | 193 ± 42 (4) |
Values are means ± SE, with n in parentheses. Applications were for 40 s followed by 4-min washout periods in HEK293 cells expressing rat P2X2a receptor.
τdes, desensitization constant; Imax, maximal ATP current.