Fig. 1.

Identification of three nonsynonymous single nucleotide polymorphisms (SNPs) in the Na⁺/H⁺ exchanger 3 (NHE3) NHE3 gene. SNPs in the NHE3 gene were identified from the dbSNP(build 129) and Ensembl databases searched in 2008. Schematic diagram of the NHE3 gene and the locations of 9 SNPs in the exons are shown at top. Six silent mutations are in not underlined and three missense SNPs are underlined. All 3 missense SNPs, producing amino acid changes R474Q, V567M, and R799C, are located in the cytoplasmic tail of NHE3, as shown at bottom.