Fig. 2.

Signaling kinases are activated with exercise. A–C: blots and quantification of signaling kinases in WT and KO animals in Con, Ex, and Ex + R groups. A: representative blots of signaling kinases in WT and KO animals in Con, Ex, and Ex + R groups. Total protein and GAPDH were used as loading controls. P-AMPK and T-AMPK, phosphorylated and total AMP-activated kinase; P-p38 and T-p38, phosphorylated and total p38. B and C: quantification of signaling kinases in WT and KO animals in Con, Ex, and Ex + R groups. AU, arbitrary units. Values are means ± SE; n = 5–9. *P < 0.05, significant effect of exercise. †P < 0.05, significant effect of genotype.