Table 2.
Risk of birth defects according to first trimester dispensing of any ARV or specific ARV class (N= 806 Infants)
| Exposure Group | Na | Birth Defect (N = 32) | % Prevalence | Adjusted ORb (95% CI) |
|---|---|---|---|---|
| Unexposed | ||||
| Any ARV | 585 | 23 | 3.9 | ref |
| Exposed | ||||
| Any ARV | 221 | 9 | 4.1 | 1.07 (0.50, 2.31) |
| NRTIs | 217 | 9 | 4.1 | 1.09 (0.51, 2.34) |
| NNRTIs | 50 | 0 | 0 | --- |
| PIs | 89 | 5 | 5.6 | 1.76 (0.62, 4.94) |
ARV: antiretroviral; NRTIs: nucleoside reverse transcriptase inhibitors; NNRTIs: non-nucleoside reverse transcriptase inhibitors; PIs: protease inhibitors; OR: odds ratio; CI: confidence interval
a
These are non-mutually exclusive groups
b
Logistic regression models adjusted for calendar year of delivery (categorical), maternal age (continuous) and race (categorical) were utilized.