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. 2015 Jan 28;35(5):818–827. doi: 10.1038/jcbfm.2014.255

Figure 1.

Figure 1

Blood–brain and blood–cerebrospinal fluid (CSF) barrier permeability after neonatal hypoxia-ischemia (HI). (A) Sucrose concentration ratios between the left (ligated) and right hemisphere in animals at different times after HI. Thus, ratios over 1 indicate an increase in blood–brain barrier permeability in the injured hemisphere. At 2 hours (2 hours), only hippocampal ratios were significantly higher than control values. The highest ratios were present at 6 hours after HI and these were significantly higher than control ratios in hippocampus, cortex, and in thalamus/striatum. Ratios were lower at 24 hours than at 6 hours but still significantly different in hippocampus and cortex from control values. At all other times and regions no statistical difference was detected between ratios. (B) Sucrose CSF/plasma concentration ratios in P9 control animals and at 2 to 24 hours after HI with no significant differences detected between HI and control animals. Data are mean±s.e.m., n=6 to 14/group; *P<0.05, **P<0.01, ***P<0.001 compared with controls (ANOVA followed by LSD).