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. 2015 Jan 21;35(5):835–842. doi: 10.1038/jcbfm.2014.260

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Copyright © 2015 International Society for Cerebral Blood Flow & Metabolism, Inc.

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Evaluation of cholesterol depletion in vascular smooth muscle (VSM) cells by β-cyclodextrin (β-CD). (A) Human brain VSM cells (HBVSMCs) treated with U18666A (U18666A group) showed intracellular accumulation of cholesterol in perinuclear vacuoles, based on filipin III staining. HBVSMCs treated with β-CD (β-CD group) showed a marked decrease in filipin III staining compared with nontreated cells (Control group). All cells stained with filipin III were counterstained with rhodamine phalloidin to visualize F-actin. Bars, 50 μm. (B) The mean % filipin III intensity of HBVSMCs treated with β-CD showed a marked decrease (n=35). Values are shown as means+s.d. ^##P<0.001 versus control group.