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. 2015 Jan 7;35(4):601–610. doi: 10.1038/jcbfm.2014.233

Figure 5.

Figure 5

Relationships between spectral linewidth changes, blood oxygenation level–dependent functional magnetic resonance imaging (BOLD-fMRI) amplitudes, metabolite concentrations, and their changes during the visual stimulation studies. (A) Scatter plot showing linewidth changes of creatine (Cr) signals (3 p.p.m.) between REST (resting) and STIM (stimulation) conditions (ΔFWHMCr) assessed from the 27-minute functional magnetic resonance spectroscopy (fMRS) paradigm, relative to linewidth changes of water signals between REST and STIM conditions (ΔFWHMwater) determined from the short stimulation paradigm (1.5 minutes). Dashed line represents the line of identity. (B) Correlation between water signal–linewidth changes (REST−STIM) and BOLD signal amplitudes (averaged across the volume selected for fMRS) assessed from the fMRI data (R=0.93, P=0.0001). (C and D) Correlation of BOLD-fMRI amplitudes with the relative concentration changes of glutamate (Glu; R=0.73, P=0.01; C) and lactate (Lac; R=0.65, P=0.003; D) in response to visual stimulation. (E) Correlation between the baseline resting–state γ-aminobutyric acid (GABA) concentration and the BOLD-fMRI amplitudes (R=−0.65, P=0.043).