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. 2015 Jan 7;35(4):565–575. doi: 10.1038/jcbfm.2014.252

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Copyright © 2015 International Society for Cerebral Blood Flow & Metabolism, Inc.

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Consecutively applied pulses within one stimulation train and between consecutive stimulation trains caused variations in the electrophysiologic responses of the right CA1 pyramidal cells. (A) Development of the field excitatory postsynaptic potential (fEPSP) slopes and latencies in the right CA1 region during repetitive electrical stimulation of the left CA3a/b region with low-intensity (trains 1 to 10), high-intensity (trains 1 to 20), and again low-intensity stimulation trains (trains 21 to 30). During each train, 16 responses were recorded. The response to the first low-intensity stimulation pulse in train 1 was set to 100% (n=6). (B) Development of the fEPSP slopes and latencies and population spike amplitudes and latencies in the right CA1 region during repetitive electrical stimulation of the left CA3c region with low-intensity (trains 1 to 10), high-intensity (trains 1 to 20), and again low-intensity stimulation trains (trains 21 to 30). The fEPSP response to the first low-intensity stimulation pulse in train 1 was set to 100% and the population spike response to the first high-intensity pulse was set to 100% (n=6). The inserts represent the average development of the population spike amplitudes and latencies during the high-intensity stimulation trains (n=6, significant change to the first response is indicated by an asterisk (paired Student's t-test, df: 5). (C) Upper row: Plot of the averaged responses to all 16 pulses per train to depict variations in neuronal activity during consecutive trains. Lower row: Plot of the average responses to consecutive pulses during the initial low-intensity trains (i.e, trains 1 to 10; gray dots), the high-intensity stimulation trains (i.e., trains 11 to 20, dark blue dots (group A) or dark red dots (group B)) and the following low-intensity stimulation trains (i.e., trains 21 to 30; gray blue (group A) or gray red (group B)). Asterisks show significant lower responses in comparison with the corresponding first pulse during the high-intensity stimulation train (paired Student's t-test, n=6, df: 5).