Figure 2.

Intracortical chronic gliotic microinfarct with cavitation (indicated by arrow), identified on magnetic resonance imaging (MRI), in postmortem brain of an 86-year-old female with moderate Alzheimer pathology (Braak & Braak (BB) IV). The intracortical gliotic microinfarct with cavitation appeared hyperintense on T2 (A, enlarged in B), and hypointense surrounded by a hyperintense rim on FLAIR (C). On T2* the lesion was visible as a formalin filled cavity (D). This microinfarct was visible on gross pathology (E). On Hematoxylin & Eosin (HE) the microinfarct was identified as a region of tissue pallor, with neuronal death, gliosis, and accompanied by a cavity (F). The cavity was surrounded by a rim of gliosis, as indicated on the adjacent GFAP-positive section (G), corresponding to the hyperintense rim on FLAIR (C). FLAIR, fluid-attenuated inversion recovery; GFAP, glial fibrillary acidic protein.