Fig. 8.
Dependency of oxygen consumption rate on Δψm for different Δψm-producing and -dissipating kinetic modules (left), with oxygen consumption rates at Δψm of −170 mV (right), for mitochondria isolated from total skeletal muscle of septic, fed sham, and fasted sham mice. A and B: proton leak kinetics; C and D: total Δψm-dissipating pathways (proton leak + ATP turnover reactions) under state 3 conditions; E and F: ATP turnover kinetics (phosphorylation + transport reactions) - kinetic curves derived from subtraction of A from C; G and H: substrate (succinate) oxidation kinetics. *P < 0.05 1-way ANOVA significance of septic vs. both sham groups; **P < 0.05 1-way ANOVA starved sham vs. fed sham and septic groups.