Fig. 6.

Tbxas deficiency attenuates fibrosis in adipose tissue of HFD-fed mice. A and B: representative histology images of formalin-fixed, paraffin-embedded tissue sections from epididymal adipose tissues of HFD-fed Tbxas WT and KO mice stained with hematoxylin and eosin (A) or Masson's trichrome (B), which allows visualization of collagen deposition (blue) in extracellular matrices of adipose tissue. Images are shown at ×100 and ×400 magnification. C–H: expression of Col1 (C), Col3 (D), Col6 (E), F4/80 (F), Cd11c (G), and Nos2 (H) in eWAT and iWAT white adipose tissues of Tbxas WT and KO mice (n = 10). Expression data were normalized to 18S rRNA in each sample. All data are expressed as means ± SE. *P < 0.05.