FIG 1.

Identification of natural compounds that protect ARPE-19 cells from oxidative stress-induced cell death. (A) Time frame of the screening. (B) Dot graph showing the effect of the compounds in RPE cell survival. The x axis represents compounds screened; the y axis represents cell survival after the induction of oxidative stress. The red line is a cutoff point for the compounds that protected >50% of the cells. (C) Three compounds identified in secondary screening showing protection of RPE death under two different concentrations: 4-acetoxyphenol (4-AC), ebselen, and gossypol acetic acid (GAA). *, P < 0.05; **, P < 0.01; ***, P < 0.001.