FIG 7.

YFP-SGK1 Overexpression in the SNpc after 28 days. AdV-YFP-SGK1 was injected into the striatum of mice treated with saline or treated with MPTP, and 28 days later YFP-SGK1 expression was assessed. TH immunohistochemistry is shown for a representative saline-treated mouse and for an MPTP-treated mouse in which AdV-SGK1 was overexpressed for 21 days prior to MPTP treatment. A total of 1 × 10¹⁰ viral particles of AdV-SGK1 were injected into the striatum 21 days prior to an acute treatment regimen of 18 mg/kg MPTP (1 dose every 2 h for 4 doses).