TABLE 5.
Metastasis formation is inhibited by ectopic miR-1 expressiona
| Cell line | No. of mice with metastasis/total no. |
|||
|---|---|---|---|---|
| Week 3 |
Week 10 |
|||
| Brain | Bone | Brain | Bone | |
| DU145/RasB1 | 9/10 | 10/10 | NA | NA |
| DU145/RasB1/miR-1 | 0/10 | 0/10 | 8/10 | 2/10 |
a
The presence of metastasis was assessed every 2 weeks using BLI in mice inoculated with the indicated cell lines by intracardiac injection. Mice demonstrating persistent BLI signals were counted. Metastases were verified by X-ray (bone) and pathological analysis (bone and brain). NA, not applicable.