TABLE 2.
MICs of ribosome-targeting antibiotics for Streptomyces strains
| Strain | MIC (μg/ml)a |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cli | Cm | Ery | Gen | Lin | Sm | Tet | Tsp | Tyl | |
| S. coelicolor A3(2) 1147 | 30 | 20 | 8 | 0.5 | 80 | 2.5 | 500 | 2 | 20 |
| S. lividans 1326 | 30 | 20 | 8 | 0.7 | 60 | 4 | 500 | 2 | 20 |
| S. lividans SLE299b | ND | ND | ND | ND | >1,000 | ND | ND | ND | ND |
| S. griseus IFO 13189 | ND | ND | ND | ND | 50 | ND | ND | ND | ND |
a
Determined after incubation on an MR5 agar plate for 7 days [S. coelicolor A3(2), S. lividans 1326, and S. lividans SLE299] or a GYM agar plate for 3 days (S. griseus IFO 13189). Abbreviations: Cli, clindamycin; Cm, chloramphenicol; Ery, erythromycin; Gen, gentamicin; Lin, lincomycin; Sm, streptomycin; Tet, tetracycline; Tsp, thiostrepton; Tyl, tylosin; ND, not determined.
b
Lincomycin-resistant mutant strain (25).