FIG 2.

Effect of PRMSE, with and without ciprofloxacin, on eradication of monoculture biofilms on silicone discs of E. coli CFT073 (A), P. mirabilis HI4320 (B), P. aeruginosa PAO1 (C), and P. aeruginosa PA14 (D). The graph presents recovered bacterial cells from biofilm on silicone discs versus different subinhibitory concentrations of ciprofloxacin for each strain exposed to PBS (control) or in PBS amended with subinhibitory concentrations of PRMSE (3.13, 6.25, and 12.5 mg ml⁻¹). Error bars show the standard deviations of values obtained from three replicates. Statistically significant differences are indicated for each sample treated with PRMSE plus ciprofloxacin compared to the control (sample treated with the corresponding concentration of ciprofloxacin only) (**, P < 0.01; ***, P < 0.001) and also for samples treated with PRMSE plus ciprofloxacin compared to sample treated with the same concentration of PRMSE without ciprofloxacin (*, P < 0.05). The legend in each graph shows the concentration of PRMSE.