TABLE 2.
Synergistic interactions of ciprofloxacin and PRMSE for growth inhibition
| Bacterial strain | Value for measure of interaction |
|||||
|---|---|---|---|---|---|---|
| Ciprofloxacin |
PRMSE |
FICIb | Synergistic | |||
| MIC (μg ml−1) | FICa | MIC (mg ml−1) | FICa | |||
| E. coli CFT073 | 0.008 | 0.25 | 25 | 0.13 | 0.38 | Yes |
| P. mirabilis HI4320 | 0.016 | 0.02 | 50 | 0.13 | 0.14 | Yes |
| P. aeruginosa PAO1 | 1 | 0.03 | 50 | 0.06 | 0.1 | Yes |
| P. aeruginosa PA14 | 0.06 | 0.03 | 50 | 0.06 | 0.1 | Yes |
a
FIC, fractional inhibitory concentration. FIC is the MIC of compound 1 in the combination divided by the MIC of compound 1 alone.
b
FICI, FIC index (FICI = FICcompound 1 + FICcompound 2).