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Induced effects of CYP3A4/2B6/2C9 mediated via PXR by helicid (a) and its metabolites I (b), II (c) (). There was a significant difference between positive control and 0.1% DMSO treatment group (* P < 0.01), but there was no significant difference between helicid and its metabolites I, II and 0.1% DMSO treatment group (P > 0.05).
