Table 2.

Animal studies examining the renal protective effect of vitamin D analogues

			Benefit
				Renal
Study	Model	Treatment	Proteinuria	function	Histology	Remarks
Schwarz et al. [24]	Subtotally nephrectomy	Calcitriol	Reduce	n/a	Less glomerulosclerosis	No change in BP; benefit not related to PTH
Hirata et al. [25]	Subtotally nephrectomy	22-oxacalcitriol	Reduce	n/a	Less glomerulosclerosis
Mizobuchi et al. [26]	Subtotally nephrectomy	Paricalcitol	Reduce	Improve	Less glomerulosclerosis	Possibly a higher TI volume
Migliori et al. [27]	Thy1.1 glomerulonephritis	Calcitriol	Reduce	n/a	Less glomerular damage
Tan et al. [28]	Obstructive nephropathy	Paricalcitol	n/a	n/a	Less TI damage

BP, blood pressure; PTH, parathyroid hormone; TI, tubulointerstitial; n/a, not assessed.