Table 4.

Regulogs Identified in S. aureus

The regulogs were constructed by performing Regulogger analysis on regulons in S. aureus using the genomes of B. subtilis, L. monocytogenes, and B. halodurans. The regulons in S. aureus were obtained by performing a site search with the matrices obtained by phylogenetic footprinting using a site score threshold P < 0.03. The regulogs are sorted on the basis of their scores, which represent average relative conservation score (RCS) of the regulog members. The regulogs with the highest scores are thus composed of members for which the regulatory signal is highly conserved across multiple genomes. The function of the regulogs was determined by assigning a functional category to each gene of S. aureus on the basis of the function of its ortholog in B. subtilis. The functional categories for the genes of B. subtilis were taken from the SubtilList webserver (http://genolist.pasteur.fr/SubtiList/). The functional category with the highest degree of over-representation is shown. For regulogs that were merged on the basis of the similarity of their corresponding matrices, the score of the highest scoring regulog is given.