Table 10.
Human studies on chemically induced changes in miRNA expression.
| miRNA | miR function | Regulation | Tissue/cell type | Chemical | Source |
|---|---|---|---|---|---|
| miR-191 | OncomiR | Up | Peripheral blood | PCB-169 | Guida et al. 2013 |
| miR-146a | Inflammation, NFκβ mediator | Up | Fetal brain cells | Aluminum | Pogue et al. 2009 |
| miR-9 | Neuronal differentiation | ||||
| miR-125b | Targets p53, stress response | Up | Fetal brain cells | Aluminum | Lukiw and Pogue 2007 |
| miR-128 | Apoptosis | ||||
| miR-199a | Oncogene activation | Up | Serum | PFOA | Wang J et al. 2012 |
| miR-21 | Fatty acid biosynthesis, apoptosis | Up | Blood samples | Arsenic | Kong et al. 2012 |
| miR-26b | Wnt, p53, autophagy, TGF-β | ||||
| Let-7a | Cell proliferation, angiogenesis | Up | Cord blood | Arsenic | Rager et al. 2014 |
| miR-16 | p53, cell cycle, JAK/STAT | ||||
| miR-17 | DNA damage response | ||||
| miR-20a | Angiogenesis | ||||
| miR-20b | Hypoxia | ||||
| miR-26b | Wnt, p53, autophagy, TGF-β | ||||
| miR-96 | Several unrelated targets | ||||
| miR-98 | Apoptosis | ||||
| miR-107 | Targets Notch2 | ||||
| miR-126 | Angiogenesis | ||||
| miR-195 | Tumor suppressomiR | ||||
| miR-454 | Unknown | ||||
| miR-24 | OncomiR | Down | Plasma | PAH | Deng et al. 2014 |
| miR-27a | Apoptosis, ERα | ||||
| miR-28 | Apoptosis | ||||
| miR-142 | Immunology | ||||
| miR-150 | Hematopoeiesis | Up | Plasma | PAH | Deng et al. 2014 |
| Abbreviations: OncomiR, miR with oncogenic properties; PAH, polycyclic aromatic hydrocarbon; suppressomiR, tumor suppressor miR. | |||||