Table 3.

In vivo studies on the effects of smoking on differential miRNA expression.

miRNA	miR function	Regulation	Tissue/cell type	Source
miR-34b	p53 effector	Down	Mouse lung	Izzotti et al. 2011
miR-421	Targets SMAD4, polycomb gene CBX7, ATM
miR-450b	No validated targets
miR-466	No validated targets
miR-469	Mouse miR not validated
miR-135b	Inflammation, oxidative stress	Up	Mouse lung	Halappanavar et al. 2013
miR-206	Targets SERP1, BDNF, FOXP1	Up	Rat serum	Wu et al. 2013
miR-133b	Targets LAG1, PTBP2
miR-20b	Hypoxia	Down	Mouse lung and plasma	Huang et al. 2012
miR-30e	Targets UBC9, UBE21, MUC17
miR-125b	Targets p53, stress response
miR-128	Apoptosis
let-7a	Cell proliferation, angiogenesis	Down	Mouse lung	Izzotti et al. 2009
let-7b	Cell proliferation, angiogenesis
let-7f	Cell proliferation, angiogenesis
miR-26a	Transforming growth factor expression
miR-30b	Cell adhesion, stress response
miR-30c	Cell cycle, oncogene activation
miR-34b	p53 effector
miR-99b	Apoptosis
miR-122a	Stress response
miR-124a	Stress response, cell growth and differentiation
miR-125a	Oncogene activation, ROS
miR-125b	Targets p53, stress response
miR-140	p53 effector
miR-192	Oncogene activation
miR-431	Protein repair, oncogene activation
miR-92b	Tumor suppressomiR	Down	Mouse serum	Yuchuan et al. 2014
miR-668	Inflammation
miR-700	Inflammation
Let-7e	Apoptosis	Up	Mouse serum	Yuchuan et al. 2014
miR-19a	OncomiR
miR-142	Immunology
miR-191	OncomiR
miR-350	Unknown
Abbreviations: oncomiR, miR with oncogenic properties; ROS, reactive oxygen species; suppressomiR, tumor suppresor miR.