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. 2015 Mar 10;47(5):177–186. doi: 10.1152/physiolgenomics.00138.2014

Fig. 3.

Fig. 3.

Similar mechanisms of regulation by SRY and SOX3 on promoters of AGT and ACE2. A: activation of the AGT promoter with 2 concentrations of transfected SRY (light gray) or SOX3 (dark gray). In addition, a double transfection of SRY and SOX3 (checkered) shows nonadditive activation suggesting shared mechanisms of promoter control. B: repression of the ACE2 promoter with 2 concentrations of transfected SRY (light gray) or SOX3 (dark gray). In addition a double transfection of SRY and SOX3 (checkered) shows nonadditive repression, suggesting shared mechanisms of promoter control. Error bars are shown as the SE. Each sample is compared with the control for each promoter. *Significant differences (P ≤ 0.05).