Table 3. Aminative multifunctionalization of terminal alkynes with NFR1–4.

Reactions condition: 1 (0.2 mmol), NFR1–4 (1.5 equiv., 0.3 mmol), CH₃OH (3 equiv., 0.6 mmol), Cu(OTf)₂ (10 mol %) and TFA (1.0 equiv., 0.2 mmol) in CH₃CN (2 ml) at 90 °C under N₂ atmosphere for 8 h. Isolated yields.

*Mixture of two isomers. The ratio was determined by ¹H NMR analysis.