Table 4. Aminative multifunctionalization of internal alkynes with NFSI.

NFSI, N-fluorobenzenesulfonimide.

Reactions condition: 6 (0.5 mmol), NFSI (1.5 equiv., 0.75 mmol), i-PrOH (1.5 equiv., 0.75 mmol), CuCN (5 mol %) and ZnCl₂ (2 mol %) in CH₂Cl₂ (2 ml) at 70 °C under N₂ atmosphere for 12 h. Isolated yields.

*Mixture of two isomers. The ratio was determined by ¹H NMR analysis.