. Author manuscript; available in PMC: 2015 May 6.

Published in final edited form as: J Infect Dis. 2010 Feb 1;201(3):399–408. doi: 10.1086/650344

Table 2.

Semiquantitative Analysis of the Extent and Organization of the Inflammatory Response in Hematoxylin and Eosinstained Lung Sections

Variable	WT	fat1
Percentage of area compromised^a
Time postinfection
Uninfected	20.98 ± 1.8	22.46 ± 0.8^b
1 day	29.28 ± 1.1	26.49 ± 2.7^b
2 weeks	26.19 ± 1.1	22.68 ± 1.2^b
4 weeks	32.10 ± 1.3	29.05 ± 1.0^b
8 weeks	44.67 ± 1.2	38.91 ± 1.00^c
Degree of inflammation^d
Time postinfection
Uninfected	0.4 ± 0.1	0.30 ± 0.1
1 day	1.0 ± 0.2	0.5 ± 0.2^b
2 weeks	1.4 ± 0.1	0.7 ± 0.1^c
4 weeks	1.9 ± 0.2	1.4 ± 0.2^b
8 weeks	2.5 ± 0.1	1.7 ± 0.2^c
Granulomatous organization^e
Time postinfection
Uninfected	0 ± 0	0± 0
1day	0± 0	0± 0
2 weeks	0 ± 0	0± 0
4 weeks	1.8 ± 0.1	2.5 ± 0.2^b
8 weeks	1.8 ± 0.1	2.7 ± 0.1^b

The percentage of tissue involved in the inflammatory response was determined as described in Materials and Methods.

P<.01.

P<.001.

The degree of inflammation was scored from 0 to 3 (0, no inflammation; 1, mild; 2, confluent inflammatory cells; 3, extended infiltrate).

The granulomatous organization was scored from 0 to 3 (0, no lesions; 1, well-organized infiltrate; 2, reduced organization; 3, the least organized granulomatous foci).