Table 1.

CDT and VDT Reproducibility: Test 1 vs. Test 4 and Means of Trial 1 vs. Trial 2

Measure	CDT Test 1	CDT Test 4	VDT Test 1	VDT Test 4
Mean JND	16.9 ± 4.73	16.20 ± 5.17	21.08 ± 1.88	20.42 ± 3.62
Approximate Change from Baseline	−7.3	−5.2	172.5	120
(°C for CDT or μm for VDT )
ICC	0.80	0.80	0.75	0.75
Measure	CDT	CDT	VDT	VDT
	MeanTrial 1	MeanTrial 2	MeanTrial 1	MeanTrial 2
Mean JND	16.23 ± 5.18	15.85 ± 5.63	21.32 ± 1.94	20.64 ± 3.45
Approximate Change from Baseline	−5.3	−4.5	172	127
(°C for CDT or μm for VDT )
ICC	0.83	0.83	0.55	0.55

JND: Just noticeable difference: discrete magnitudes of stimulation by the CASE IV device exponential algorithmic function; CDT, cold detection threshold; VDT, vibration detection threshold; ICC, intra-class correlation coefficient. Approximate change from baseline is mean of minimum degrees of temperature/ μm vibration required for patients to perceive stimulus from baseline temperature/ vibration at beginning of CASE IV testing paradigm.