Table 1.

Parameter Values

Param.	Value	Unit	Description	Reference
δx	20	µm	Diameter of CA grid point	Model specific
pD	0.005	1/day	Normal tissue death rate	[42]
pδ	0.7	1/day	Death prob. in poor conditions	Model specific
pn	5×10−4	1/day	Necrotic turnover rate	Model specific
DO	1820	µm2/s	Diffusion rate of O2	[43]
DG	500	µm2/s	Diffusion rate of glucose	[44]
DH	1080	µm2/s	Diffusion rate of protons	[40]
DC	100	µm2/s	Diffusion rate of chemo	Model specific
Oo	0.056	mM	O2 concentration in blood	[45]
Go	5	mM	Glucose concentration in blood	[46]
pHo	7.4	pH	pH of blood	Physiologic pH
VO	0.012	mM/s	Max. O2 concentration	[45]
kO	0.005	mM	Half-max O2 consumption	[47]
kG	0.04	mM	Half-max glucose consumption	[47]
kH	2.5×10−4	—	Proton buffering coefficient	[40]
βN	6.65	pH	Normal acid resistance	[48]
βT,min	6.1	pH	Maximal acid resistance	[47]
pG,max	50	—	Maximal glycolytic phenotype	[49]
ΔH	0.001	—	Pheno. Variation rate (acid res.)	Model specific
ΔG	0.05	—	Pheno. Variation rate (glycolysis)	Model specific
Ad	0.3	—	ATP threshold for death	Model specific
Aq	0.8	—	ATP threshold for quiescence	Model specific
τmin	0.8	Day	Min. cell cycle time	[47]
σmin	80	µm	Min. vessel spacing	[50]
σmean	158	µm	Mean vessel spacing	[50]
ζO	[8,20]×10−4	mM	Hypoxic angiogenesis zone	Model specific
νmean	20	—	Vessel stability	Model specific
pang	0.3	—	Angiogenesis rate	Model specific
Co	1	—	Chemo concentration in blood	Model specific
Cd	0.25	—	Min chemo conc. half-max	Model specific