Figure 2. Additional observations in neuropsychiatric disease. An updated version of Figure 1 shows types of genetic variants now thought to explain some of the genetic risk of neuropsychiatric diseases, including certain rare copy number variants (CNVs) with large effects. Falling outside the predicted inverse linear relationship between allele frequency and effect size, are the presence of any de novo CNV and the contribution of common alleles when incorporated into a polygenic model.
