Table 2.
Distributions of toll-like receptor genotypes in the three groups
| dbSNPS | Genotypes | Frequencies (No., %) | LTBI.vs.HC | TB.vs.LTBI | TB.vs.HC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HC ( n = 422) | LTBI ( n = 225) | TB ( n = 109) | p | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | ||
| rs5743618 | GG | 2(0.5) | 2(0.9) | 1(0.9) | 0.613 | 1.883 | 0.264-13.461 | 0.979 | 1.032 | 0.093-11.511 | 0.499 | 1.944 | 0.175-21.64 |
| TG | 70(16.6) | 23(10.2) | 10(9.2) | 0.028 | 0.573 | 0.347-0.946 | 0.763 | 0.887 | 0.407-1.936 | 0.054 | 0.508 | 0.252-1.022 | |
| TT | 350(82.9) | 200(88.9) | 98(89.9) | 0.043 | 1.646 | 1.011-2.678 | 0.778 | 1.114 | 0.526-2.356 | 0.074 | 1.833 | 0.935-3.592 | |
| rs3804099 | CC | 51(12.1) | 25(11.1) | 9(8.3) | 0.714 | 0.909 | 0.547-1.512 | 0.419 | 0.720 | 0.324-1.600 | 0.260 | 0.655 | 0.312-1.375 |
| TC | 180(42.6) | 95(42.2) | 36(33.0) | 0.916 | 0.982 | 0.708-1.363 | 0.107 | 0.675 | 0.418-1.089 | 0.068 | 0.663 | 0.426-1.033 | |
| TT | 191(45.3) | 105(46.7) | 64(58.7) | 0.732 | 1.058 | 0.765-1.464 | 0.039 | 1.625 | 1.023-2.581 | 0.012 | 1.720 | 1.123-2.636 | |
| rs5743708 | GA | 4(0.9) | 9(4.0) | 6(5.5) | 0.008 | 4.354 | 1.326-14.301 | 0.534 | 1.398 | 0.485-4.033 | 0.002 | 6.087 | 1.687-21.968a |
| GG | 418(99.1) | 216(96.0) | 103(94.5) | 0.008 | 0.229 | 0.051-0.836 | 0.534 | 0.715 | 0.221-2.513 | 0.002 | 0.164 | 0.046-0.593a | |
| rs3804100 | CC | 42(10.0) | 45(20.0) | 21(19.2) | <0.001 | 2.262 | 1.433-3.570a | 0.875 | 0.955 | 0.536-1.700 | 0.007 | 2.159 | 1.218-3.829 |
| TC | 168(39.8) | 90(40.0) | 44(40.4) | 0.963 | 1.008 | 0.724-1.402 | 0.949 | 1.015 | 0.637-1.619 | 0.916 | 1.023 | 0.666-1.572 | |
| TT | 212(50.2) | 90(40.0) | 44(40.4) | 0.013 | 0.660 | 0.476-0.917 | 0.949 | 0.985 | 0.618-1.570 | 0.066 | 0.671 | 0.437-1.028 | |
| rs1898830 | AA | 142(33.6) | 68(30.2) | 33(30.3) | 0.375 | 0.854 | 0.602-1.211 | 0.992 | 1.003 | 0.609-1.649 | 0.504 | 0.856 | 0.543-1.351 |
| AG | 196(46.4) | 113(50.2) | 54(49.5) | 0.360 | 1.163 | 0.842-1.608 | 0.907 | 0.973 | 0.616-1.538 | 0.564 | 1.132 | 0.743-1.725 | |
| GG | 84(20.0) | 44(19.6) | 22(20.2) | 0.915 | 0.978 | 0.651-1.469 | 0.893 | 1.040 | 0.587-1.843 | 0.948 | 1.018 | 0.602-1.720 | |
| rs4986790 | AA | 346(82.0) | 181(80.4) | 77(70.6) | 0.630 | 0.904 | 0.598-1.365 | 0.045 | 0.585 | 0.345-0.991 | 0.009 | 0.529 | 0.327-0.855 |
| AG | 75(17.8) | 42(18.7) | 31(28.4) | 0.778 | 1.062 | 0.699-1.613 | 0.043 | 1.732 | 1.094-3.050 | 0.013 | 1.839 | 1.132-2.987 | |
| GG | 1(0.2) | 2(0.9) | 1(0.9) | 0.245 | 3.776 | 0.341-41.869 | 0.979 | 1.032 | 0.093-11.51 | 0.369 | 3.898 | 0.242-62.825 | |
| rs4986791 | CC | 342(81.0) | 179(79.6) | 74(67.9) | 0.649 | 0.910 | 0.607-1.365 | 0.020 | 0.543 | 0.324-0.911 | 0.003 | 0.495 | 0.309-0.791 |
| CT | 76(18.0) | 43(19.1) | 32(29.4) | 0.730 | 1.076 | 0.710-1.629 | 0.035 | 1.759 | 1.036-2.987 | 0.009 | 1.892 | 1.169-3.061 | |
| TT | 4(1.0) | 3(1.3) | 3(2.7) | 0.699 | 1.412 | 0.313-6.365 | 0.396 | 2.094 | 0.416-10.551 | 0.141 | 2.958 | 0.652-13.415 | |
| rs11536889 | CC | 34(8.1) | 17(7.6) | 10(9.2) | 0.822 | 0.933 | 0.509-1.701 | 0.611 | 1.236 | 0.546-2.798 | 0.706 | 1.153 | 0.551-2.413 |
| GC | 167(39.5) | 86(38.2) | 40(36.7) | 0.737 | 0.945 | 0.678-1.317 | 0.787 | 0.937 | 0.584-1.504 | 0.583 | 0.885 | 0.573-1.368 | |
| GG | 221(52.4) | 122(54.2) | 59(54.1) | 0.653 | 1.077 | 0.779-1.490 | 0.987 | 0.996 | 0.630-1.577 | 0.743 | 1.073 | 0.703-1.637 | |
| rs10759932 | CC | 42(10.0) | 21(9.3) | 5(4.5) | 0.800 | 0.931 | 0.537-1.616 | 0.129 | 0.467 | 0.171-1.274 | 0.079 | 0.435 | 0.168-1.127 |
| TC | 168(39.8) | 90(40.0) | 49(45.0) | 0.963 | 1.008 | 0.724-1.402 | 0.389 | 1.225 | 0.772-1.945 | 0.330 | 1.235 | 0.807-1.888 | |
| TT | 212(50.2) | 114(50.7) | 55(50.5) | 0.917 | 1.017 | 0.736-1.406 | 0.972 | 0.992 | 0.628-1.567 | 0.967 | 1.009 | 0.662-1.537 | |
| rs7873784 | CC | 29(6.9) | 19(8.4) | 7(6.4) | 0.467 | 1.250 | 0.684-2.283 | 0.518 | 0.744 | 0.303-1.827 | 0.868 | 0.930 | 0.396-2.184 |
| GC | 135(32.0) | 57(25.4) | 18(16.5) | 0.078 | 0.721 | 0.501-1.037 | 0.070 | 0.583 | 0.324-1.050 | 0.001 | 0.421 | 0.244-0.726a | |
| GG | 258(61.1) | 149(66.2) | 84(77.1) | 0.202 | 1.246 | 0.888-1.748 | 0.043 | 1.714 | 1.014-2.897 | 0.002 | 2.136 | 1.312-3.478a | |
| rs10759931 | AA | 143(33.9) | 90(40.0) | 44(40.4) | 0.123 | 1.301 | 0.931-1.817 | 0.949 | 1.015 | 0.637-1.619 | 0.207 | 1.321 | 0.857-2.035 |
| AG | 215(50.9) | 113(50.2) | 54(49.5) | 0.860 | 0.971 | 0.703-1.343 | 0.907 | 0.973 | 0.616-1.538 | 0.793 | 0.945 | 0.620-1.440 | |
| GG | 64(15.2) | 22(9.8) | 11(10.1) | 0.055 | 0.606 | 0.363-1.014 | 0.928 | 1.036 | 0.483-2.221 | 0.175 | 0.628 | 0.319-1.236 | |
| rs5743810 | CT | 12(2.8) | 8(3.6) | 5(4.6) | 0.618 | 1.260 | 0.507-3.128 | 0.648 | 1.304 | 0.416-4.084 | 0.357 | 1.643 | 0.566-4.766 |
| TT | 410(97.2) | 217(96.4) | 104(95.4) | 0.618 | 0.790 | 0.293-2.276 | 0.648 | 0.773 | 0.215-3.057 | 0.357 | 0.609 | 0.210-1.766 | |
| TLR8_129 | CC | 133(31.5) | 81(36.0) | 52(47.7) | 0.248 | 1.222 | 0.869-1.719 | 0.040 | 1.622 | 1.020-2.580 | 0.002 | 1.982 | 1.292-3.042a |
| CG | 190(45.0) | 96(42.7) | 41(37.6) | 0.565 | 0.909 | 0.656-1.259 | 0.379 | 0.810 | 0.507-1.295 | 0.164 | 0.736 | 0.478-1.134 | |
| GG | 99(23.5) | 48(21.3) | 16(14.7) | 0.539 | 0.885 | 0.599-1.307 | 0.147 | 0.634 | 0.342-1.178 | 0.047 | 0.561 | 0.315-0.999 | |
| rs5743836 | CC | 25(5.9) | 13(5.8) | 6(5.5) | 0.940 | 0.974 | 0.488-1.943 | 0.919 | 0.950 | 0.351-2.571 | 0.868 | 0.925 | 0.370-2.314 |
| TC | 181(42.9) | 125(55.5) | 49(45.0) | 0.002 | 1.664 | 1.201-2.306 | 0.069 | 0.653 | 0.412-1.035 | 0.698 | 1.087 | 0.712-1.661 | |
| TT | 216(51.2) | 87(38.7) | 54(49.5) | 0.002 | 0.601 | 0.433-0.836 | 0.059 | 1.557 | 0.982-2.471 | 0.760 | 0.936 | 0.614-1.427 | |
| rs1870884 | CC | 3(0.7) | 1(0.4) | 0(0) | 1.000 | 0.624 | 0.064-6.029 | - | |||||
| TC | 107(25.4) | 56(24.9) | 27(24.8) | 0.896 | 0.976 | 0.672-1.417 | 0.981 | 0.994 | 0.585-1.687 | 0.900 | 0.969 | 0.596-1.578 | |
| TT | 312(73.9) | 168(74.7) | 82(75.2) | 0.839 | 1.039 | 0.717-1.506 | 0.912 | 1.030 | 0.607-1.748 | 0.783 | 1.071 | 0.658-1.741 | |
| TIRAP_975 | CC | 313(74.2) | 153(68.0) | 61(56.0) | 0.096 | 0.740 | 0.519-1.055 | 0.032 | 0.598 | 0.374-0.957 | <0.001 | 0.443 | 0.286-0.685a |
| CT | 97(23.0) | 61(27.1) | 40(36.7) | 0.245 | 1.246 | 0.860-1.806 | 0.074 | 1.559 | 0.957-2.539 | 0.004 | 1.942 | 1.238-3.048 | |
| TT | 12(2.8) | 11(4.9) | 8(7.3) | 0.181 | 1.756 | 0.762-4.046 | 0.365 | 1.541 | 0.601-3.949 | 0.028 | 2.706 | 1.078-6.796 | |
PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control.
a p < 0.003125 (0.05/16), the difference was statistically significant after correction for multiple testing (Bonferroni correction).