Table 3.
Distribution of toll-like receptor alleles in the three groups
| dbSNPS | Frequencies (No., %) | LTBI.vs.HC | TB.vs.LTBI | TB.vs.HC | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alleles | HC ( n = 422) | LTBI ( n = 225) | TB ( n = 109) | p | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | |
| TLR1_1805 | G | 74(8.7) | 27(6.0) | 12(5.5) | 0.077 | 0.664 | 0.404-1.064 | 0.798 | 0.913 | 0.412-1.908 | 0.115 | 0.606 | 0.323-1.137 |
| T | 770(91.3) | 423(94.0) | 206(94.5) | 0.077 | 1.506 | 0.940-2.473 | 0.798 | 1.095 | 0.524-2.425 | 0.115 | 1.650 | 0.880-3.095 | |
| rs3804099 | C | 282(33.4) | 145(32.2) | 54(24.8) | 0.665 | 0.947 | 0.736-1.217 | 0.048 | 0.693 | 0.471-1.012 | 0.014 | 0.656 | 0.467-0.921 |
| T | 562(66.6) | 305(67.8) | 164(75.2) | 0.665 | 1.055 | 0.859-1.244 | 0.048 | 1.443 | 0.988-2.124 | 0.014 | 1.524 | 1.086-2.139 | |
| rs5743708 | A | 840(99.5) | 441(98.0) | 212(96.8) | 0.009 | 0.233 | 0.052-0.843 | 0.538 | 0.721 | 0.226-2.500 | 0.002 | 0.168 | 0.047-0.602a |
| G | 4(0.5) | 9(2.0) | 6(3.2) | 0.009 | 4.291 | 1.187-19.13 | 0.538 | 1.386 | 0.401-4.429 | 0.002 | 5.943 | 1.662-21.25a | |
| rs3804100 | C | 252(29.9) | 180(40.0) | 86(39.4) | <0.001 | 1.566 | 1.223-2.003a | 0.892 | 0.977 | 0.692-1.378 | 0.007 | 1.531 | 1.124-2.085 |
| T | 592(70.1) | 270(60.0) | 132(60.0) | <0.001 | 0.638 | 0.499-0.818a | 0.892 | 1.023 | 0.742-1.387 | 0.007 | 0.653 | 0.480-0.890 | |
| rs1898830 | A | 480(56.9) | 249(55.3) | 120(55.0) | 0.595 | 0.939 | 0.741-1/191 | 0.944 | 0.988 | 0.705-1.387 | 0.628 | 0.929 | 0.688-1.253 |
| G | 364(43.1) | 201(44.7) | 98(45.0) | 0.595 | 1.064 | 0.840-1.349 | 0.944 | 1.012 | 0.721-1.419 | 0.628 | 1.077 | 0.798-1.453 | |
| rs4986790 | A | 767(90.9) | 404(89.8) | 185(84.9) | 0.521 | 0.882 | 0.591-1.325 | 0.065 | 0.638 | 0.385-1.068 | 0.009 | 0.563 | 0.363-0.872 |
| G | 77(9.1) | 46(10.2) | 33(15.1) | 0.521 | 1.133 | 0.754-1.691 | 0.065 | 1.567 | 0.937-2.595 | 0.009 | 1.777 | 1.146-2.754 | |
| rs4986791 | C | 760(90.0) | 401(89.1) | 180(82.6) | 0.597 | 1.104 | 0.690-1.556 | 0.018 | 0.579 | 0.309-0.838a | 0.002 | 0.524 | 0.345-0.794a |
| T | 84(10.0) | 49(10.9) | 38(17.4) | 0.597 | 0.905 | 0.642-1.449 | 0.018 | 1.727 | 1.193-3.235a | 0.002 | 1.910 | 1.260-2.896a | |
| rs11536889 | C | 235(27.8) | 120(26.7) | 60(72.5) | 0.651 | 0.942 | 0.721-1.228 | 0.815 | 1.044 | 0.712-1.523 | 0.925 | 0.984 | 0.705-1.373 |
| G | 609(72.2) | 330(73.3) | 158(27.5) | 0.651 | 1.061 | 0.814-1.386 | 0.815 | 0.958 | 0.657-1.404 | 0.925 | 1.016 | 0.728-1.418 | |
| rs10759932 | C | 252(29.9) | 132(29.3) | 59(27.1) | 0.844 | 0.975 | 0.752-1.262 | 0.543 | 0.894 | 0.611-1.300 | 0.419 | 0.872 | 0.625-1.216 |
| T | 592(70.1) | 318(70.7) | 159(72.9) | 0.844 | 1.026 | 0.792-1.330 | 0.543 | 1.119 | 0.769-1.637 | 0.419 | 1.147 | 0.822-1.601 | |
| rs7873784 | C | 193(22.9) | 95(21.1) | 32(14.7) | 0.469 | 0.903 | 0.713-1.270 | 0.047 | 0.643 | 0.401-0.912 | 0.008 | 1.632 | 1.084-2.456 |
| G | 651(77.1) | 355(78.9) | 186(85.3) | 0.469 | 1.107 | 0.787-1.403 | 0.047 | 1.555 | 1.017-2.494 | 0.008 | 0.613 | 0.407-0.923 | |
| rs10759931 | A | 501(59.4) | 293(65.1) | 142(65.1) | 0.043 | 1.278 | 0.910-1.488 | 0.995 | 1.001 | 0.704-1.429 | 0.120 | 1.164 | 0.853-10589 |
| G | 343(40.6) | 157(34.9) | 76(34.9) | 0.043 | 0.782 | 0.672-1.099 | 0.995 | 0.999 | 0.700-1.421 | 0.120 | 0.859 | 0.629-1.173 | |
| rs5743810 | C | 12(1.4) | 8(1.8) | 5(2.3) | 0.621 | 1.255 | 0.441-3.366 | 0.710 | 1.238 | 0.330-4.557 | 0.361 | 1.628 | 0.567-4.670 |
| T | 832(98.6) | 442(98.2) | 213(97.7) | 0.621 | 0.197 | 0.297-2.265 | 0.710 | 0.807 | 0.219-3.034 | 0.361 | 0.614 | 0.214-1.763 | |
| TLR_129 | C | 456(54.0) | 258(57.3) | 145(66.5) | 0.255 | 1.143 | 0.774-1.251 | 0.023 | 1.478 | 0.674-1.335 | 0.001 | 0.932 | 0.689-1.261a |
| G | 388(46.0) | 192(42.7) | 73(33.5) | 0.255 | 0.875 | 0.799-1.292 | 0.023 | 0.676 | 0.749-1.484 | 0.001 | 1.073 | 0.793-1.451a | |
| rs5743836 | C | 231(27.4) | 151(35.6) | 61(28.0) | 0.020 | 1.340 | 1.038-1.728 | 0.147 | 0.769 | 0.530-1.111 | 0.857 | 1.031 | 0.740-1.437 |
| T | 613(72.6) | 299(66.4) | 157(72.0) | 0.020 | 0.746 | 0.579-0.964 | 0.147 | 1.300 | 0.900-1.888 | 0.857 | 0.970 | 0.696-1.352 | |
| rs1870884 | C | 113(13.4) | 58(12.9) | 27(12.4) | 0.800 | 0.957 | 0.669-1.359 | 0.855 | 0.955 | 0.563-1.591 | 0.696 | 0.914 | 0.584-1.433 |
| T | 731(86.6) | 392(87.1) | 191(87.6) | 0.800 | 1.044 | 0.736-1.494 | 0.855 | 1.047 | 0.629-1.777 | 0.696 | 1.094 | 0.698-1.713 | |
| TIRAP_975 | C | 723(85.7) | 367(81.6) | 162(74.3) | 0.053 | 0.740 | 0.539-1.019 | 0.031 | 0.654 | 0.438-0.983a | <0.001 | 0.484 | 0.338-0.694a |
| T | 121(14.3) | 83(18.4) | 56(25.7) | 0.053 | 1.351 | 0.981-1.855 | 0.031 | 1.535 | 1.017-2.286a | <0.001 | 2.066 | 1.442-2.960a | |
PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control.
a p < 0.003125 (0.05/16), the difference was statistically significant after correction for multiple testing (Bonferroni correction).