Table 4.
Haplotypes of the TLR2 and TLR4 genes and their distributions in the three groups
| SNP marker | Haplotype | Frequency (No., %) | LTBI.vs.HC | PTB.vs.LTBI | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HC ( n = 422) | LTBI ( n = 225) | PTB ( n = 109) | P | OR | 95% CI | P | OR | 95% CI | ||
| rs3804099 | CC | 183(21.7) | 95(21.1) | 52(23.8) | 0.812 | 0.97 | 0.722-1.289 | 0.422 | 1.17 | 0.779-1.747 |
| rs3804100 | CT | 185(21.9) | 85(18.9) | 36(16.5) | 0.201 | 0.83 | 0.615-1.114 | 0.455 | 0.85 | 0.537-1.326 |
| TC | 103(12.2) | 56(12.4) | 18(8.3) | 0.900 | 1.02 | 0.709-1.465 | 0.106 | 0.63 | 0.341-1.129 | |
| TT | 373(44.2) | 214(47.6) | 112(51.4) | 0.247 | 1.15 | 0.904-1.450 | 0.354 | 1.17 | 0.832-1.632 | |
| rs10759931 | AT | 376(44.4) | 204(45.3) | 136(62.4) | 0.787 | 1.03 | 0.735-1.447 | <0.001a | 2.00 | 1.221-3.289 |
| rs10759932 | GT | 218(25.7) | 112(24.9) | 22(10.1) | 0.712 | 0.95 | 0.642-1.401 | <0.001a | 0.34 | 0.153-0.694 |
| GC | 156(18.5) | 88(19.6) | 6(2.8) | 0.639 | 1.07 | 0.693-1.646 | <0.001a | 0.12 | 0.022-0.379 | |
| AC | 94(11.4) | 46(10.2) | 54(24.7) | 0.614 | 0.91 | 0.511-1.578 | <0.001a | 2.89 | 1.496-5.596 | |
| rs4986790 | AC | 644(76.3) | 353(78.4) | 157(72.0) | 0.383 | 1.13 | 0.852-1.505 | 0.067 | 0.71 | 0.481-1.046 |
| rs4986791 | AT | 49(5.8) | 11(2.4) | 18(8.3) | 0.006 | 0.39 | 0.180-0.784 | 0.001a | 3.59 | 1.570-8.565 |
| GC | 33(3.9) | 9(2.0) | 0(0) | 0.065 | 0.50 | 0.209-1.083 | - | - | - | |
| GT | 118(14.0) | 77(17.1) | 43(19.7) | 0.134 | 1.27 | 0.915-1.755 | 0.409 | 1.19 | 0.766-1.833 | |
PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control.
a p < 0.003125 (0.05/16), the difference was statistically significant after correction for multiple testing (Bonferroni correction).