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. 2015 May 1;29(9):898–903. doi: 10.1101/gad.261743.115

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© 2015 Bonney et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Consequences of an additional copy of genes with copy number limits of <10 (limit 0–10, henceforth DSGs[10]) on cell proliferation. (A–F) Cells were grown as described in Figure 1. Genes were grouped into graphs according to chromosomal location. Dark-gray bars represent control strains carrying empty plasmids, light-gray bars represent the corresponding disomic strain (Dis), and striped bars represent DSG plasmid-containing strains. Empty vector CEN plasmid controls were EP1-TRP1, EP2-HIS3, and EP3-LEU2. SD is shown. (E) (**) P = 0.001. (F) (***) P = 0.0002; Student's t-test. The strains, in order, were A22361, A27036, A35953, and A36930 (A); A22361, A27093, A36953, and A36936 (B); A22361, A29730, A36950, and A36943 (C); A22361, A13975, A36954, and A36933 (D); A22361, A12685, A36950, and A36923 (E); and A22361, A28344, A36953, and A36942 (F).